منابع مشابه
Tumour suppressor genes in chemotherapeutic drug response
Since cancer is one of the leading causes of death worldwide, there is an urgent need to find better treatments. Currently, the use of chemotherapeutics remains the predominant option for cancer therapy. However, one of the major obstacles for successful cancer therapy using these chemotherapeutics is that patients often do not respond or eventually develop resistance after initial treatment. T...
متن کاملTumour Suppressor Genes—One Hit Can Be Enough
F or people who received their introduction to cancer genetics in college in the fi rst half of the 1990s, everything looked simple and straightforward. It was the stuff you could explain to sincerely interested relatives who wanted to know what you were spending your time on. There were oncogenes and there were tumour suppressor genes. Oncogenes were overactive genes and proteins that somehow ...
متن کاملIs DNA methylation of tumour suppressor genes epigenetic?
In colorectal cancer cells, a non-epigenetic transcriptional pathway that is mediated by an oncogene maintains DNA methylation of tumour suppressor genes.
متن کاملTumour suppressor genes and risk of metastasis in ovarian cancer.
The silent onset of ovarian cancer often leads to metastatic spread before diagnosis can be made. The cause remains unknown, but molecular studies are beginning to reveal some mechanisms. Inactivation of tumour suppressor genes is thought to be responsible for initiating many forms of cancer. Studies of allele loss indicate areas of genome where inactivation may occur. We recently examined the ...
متن کاملA new oncolytic adenoviral vector carrying dual tumour suppressor genes shows potent anti-tumour effect
Cancer Targeting Gene-Viro-Therapy (CTGVT) is a promising cancer therapeutical strategy that strengthens the anti-tumour effect of oncolytic virus by expressing inserted foreign anti-tumour genes. In this work, we constructed a novel adenoviral vector controlled by the tumour-specific survivin promoter on the basis of the ZD55 vector, which is an E1B55KD gene deleted vector we previously constr...
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ژورنال
عنوان ژورنال: Nature
سال: 1997
ISSN: 0028-0836,1476-4687
DOI: 10.1038/38119